LWP Interleukins Test Kit
14 vials, unboxed
Vial size: 10 x 40mm
NOTE: This kit does not come with a storage box. To see the options avaialble for storage go to our test kit accessories web page
Interleukins are produced by the body and help the immune system fight infection and cancer.
NOTE: These vials are also in the Cytokine Test Kit.
IL 01 Interleukin-1
Stimulates the growth and action of immune system cells that fight disease, by participating in the regulation of immune responses, inflammatory reactions, and hematopoiesis (development of mature blood cells). Also helps leukocytes pass through blood vessel walls to sites of infection and causes fever by affecting areas of the brain that control body temperature.
IL 02 Interleukin-2
Induces the proliferation of responsive T-cells, and acts on some B-cells, via receptor-specific binding, as a growth factor and antibody production stimulant. Linked to pruritus (itching).
IL 03 Interleukin-3
Regulates blood-cell production by controlling the production, differentiation and function of granulocytes and macrophages, so enhances the immune system's ability to fight tumor cells.
IL 04 Interleukin-4
Enhances the immune system's ability to fight tumor cells; has an important function in B-cell responses. A key regulator in humoral and adaptive immunity.
IL 05 Interleukin-5 / Eosinophil Differentiation Factor/ EDF
Regulates eosinophil growth and activation, and thus plays an important role in diseases associated with increased levels of eosinophils, including asthma and allergic rhinitis.
IL 06 Interleukin-6 / B-Cell Stimulatory Factor-2 /BSF-2
A biomarker for inflammation and chronic disease. Plays an essential role in the final differentiation of B-cells into IG-secreting cells, as well as inducing myeloma/plasmacytoma growth, nerve cell differentiation, and, in hepatocytes, acute-phase reactants. Involved in diabetes, atherosclerosis, depression Alzheimer's disease, systemic lupus erythematosus, prostate cancer and rheumatoid arthritis.
IL 07 Interleukin-7
Enhances the immune system's ability to fight tumor cells. IL-7 is made by cells in the bone marrow, and can stimulate T cells and B cells to grow. Promotes acute lymphoblastic leukemia, T cell lymphoma. Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients
IL 08 Interleukin-8 / Neutrophil Chemotactic Factor
Induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. Also induces phagocytosis once they have arrived. Known to be a potent promoter of angiogenesis (growth of new blood vessels from existing ones, and necessary for tumours to grow). Often associated with inflammation (e.g. in gingivitis and psoriasis). If a pregnant mother has high levels, there is an increased risk of schizophrenia in her offspring. High levels have also been shown to reduce the likelihood of positive responses to antipsychotic medication in schizophrenia.
IL 09 Interleukin-9
Serves as a growth factor for early lymphoid cells of both B- and T-cell lineages. supports IL-2 independent and IL-4 independent growth of helper T-cells.
IL 10 Interleukin-10 / Human Cytokine Synthesis Inhibitory Factor/ CSIF
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. Mice studies suggest it is an essential immuno-regulator in the intestinal tract.; may be relevant in Crohn's disease.
IL 11 Interleukin-11 / Adipogenesis Inhibitory Factor / AGIF
Stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. May reduce toxicity to the gastrointestinal system resulting from cancer therapy.
IL 12 Interleukin-12
Enhances the ability of the immune system to kill tumor cells and may interfere with blood flow to the tumor. involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, Measles virus, and HIV. Also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Administration of IL-12 to people suffering from autoimmune diseases was shown to worsen the autoimmune phenomena. This is believed to be due to its key role in induction of Th1 immune responses.
IL 17A Interleukin- 17A
Acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. Has been shown to have a pro-inflammatory role in asthma.
IL 23 Interleukin-23
Potently enhances the expansion of T helper type 17 cells, so involved in many of the inflammatory autoimmune responses.
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